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Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

[ Vol. 10 , Issue. 3 ]

Author(s):

Shirley S. Mihardja and Randall J. Lee   Pages 342 - 346 ( 5 )

Abstract:


Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.

Keywords:

Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis

Affiliation:

University of California San Francisco, Box 1354, San Francisco, CA 94143, USA.



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