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Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities

[ Vol. 8 , Issue. 4 ]

Author(s):

Verena K. Capellini, Andrea C. Celotto, Caroline F. Baldo, Vania C. Olivon, Fernanda Viaro, Alfredo J. Rodrigues and Paulo R.B. Evora   Pages 526 - 544 ( 19 )

Abstract:


The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. It is also known that hyperglycemia-induced oxidative stress plays a role in the development of this dysfunction. This review considers the basic physiology of the endothelium, especially related to the synthesis and function of nitric oxide. We also discuss the pathophysiology of vascular disease associated with DM. This includes the role of hyperglycemia in the induction of oxidative stress and the role of advanced glycation end-products. We also consider therapeutic strategies.

Keywords:

Endothelium, nitric oxide, diabetes, vascular dysfunction, oxidative stress, antioxidants, advanced glycation endproducts

Affiliation:

Departamento de Cirurgia e Anatomia–9° andar HC, Faculdade de Medicina de Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14048-900, Ribeirao Preto, SP, Brazil.



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