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Neuronal Regulators and Vascular Dysfunction in Raynauds Phenomenon and Systemic Sclerosis

[ Vol. 7 , Issue. 1 ]


Carmen Fonseca, David Abraham and Markella Ponticos   Pages 34 - 39 ( 6 )


Raynauds phenomenon (RP) results from an exaggerated cutaneous vasospastic response to cold or emotional stress. The mechanisms that lead to impaired cutaneous vascular tone are complex. The regulation of cutaneous vasoconstriction and vasodilation, involves altered sympathetic nerve activity and a host of neuronal regulators, including adrenergic and non-adrenergic, as well as REDOX signalling and other signalling such as the RhoA/ROCK pathway. This review summarises the literature concerning the regulation of vascular tone by neurohumoral factors that may be involved in RP and systemic sclerosis (SSc).


Vasoconstriction, adrenergic receptors, neuropeptides, Raynaud's phenomenon, systemic sclerosis


Centre for Rheumatology, Research Department of Inflammation, Royal Free and University College Medical School, University College London, Hampstead Campus, Rowland Hill Street, Hampstead, London, NW3 2PF, UK.

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