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Advanced Glycation and ROS: A Link between Diabetes and Heart Failure

[ Vol. 6 , Issue. 1 ]


Armando Rojas, Enrique Mercadal, Hector Figueroa and Miguel A. Morales   Pages 44 - 51 ( 8 )


Despite many advances achieved to date, heart failure (HF) remains a leading cause of morbidity and mortality. There is a widely-accepted consensus that HF and diabetes are strongly linked by at least 3 mechanisms: associated comorbidities, coronary atherosclerosis or a specific diabetic cardiomiopathy. For the last 2 mechanisms, advanced glycation end-products may contribute to trigger key processes relevant to HF by affecting cardiac function through cross-linking or receptor engagement. This review focuses on the main effects of advanced glycation end-products on cardiomyocytes and endothelial cell function. Some pharmacological approaches are also discussed.


Advanced glycation, heart failure, glucose imbalance, diabetes, cardiomyocytes, oxidative stress


School of Medicine, Health Sciences Faculty, Catholic University of Maule, Ave San Miguel &# 3605, Talca, Chile.

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