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Endothelin and Oxidative Stress in the Vascular System

[ Vol. 3 , Issue. 4 ]


David M. Pollock and Jennifer S. Pollock   Pages 365 - 367 ( 3 )


Both endothelin(ET)-1 and oxidative stress have been the subjects of intense investigation within the cardiovascular field over the past decade and a half, yet little is known about the precise relationship between these important modulators of vascular function. There is a firm evidence that ET-1 can stimulate the production of superoxide via NADPH oxidase activation, and at the same time, reactive oxygen species appear to stimulate ET-1 production. What is less clear is how these changes participate in the pathogenesis of vascular dysfunction. There is mixed evidence on whether oxidative stress plays a role in ET-dependent hypertension, however, a specific influence of ET-induced oxidative stress to reduce vascular reactivity is more convincing. The current review summarizes recent investigations into the relationship between ET-1 and oxidative stress and highlights several areas that require further investigation.


endothelin, superoxide, hypertension


Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd., Augusta, GA 30912-2500, USA.

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