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Pro-inflammatory Mediators and Oxidative Stress: Therapeutic Markers for Recurrent Angina Pectoris after Coronary Artery Stenting in Elderly Patients

[ Vol. 19 , Issue. 6 ]

Author(s):

Xia Li*, Dianxuan Guo, Hualan Zhou, Youdong Hu, Xiang Fang and Ying Chen   Pages 643 - 654 ( 12 )

Abstract:


Background: Pro-inflammatory mediators and oxidative stress are related to the severity of angina pectoris in patients with coronary heart disease.

Objective: We evaluated the effects of pro-inflammatory mediators and oxidative stress on recurrent angina pectoris after coronary artery stenting in elderly patients.

Methods: We determined the expression levels of malondialdehyde (MDA), acrolein (ACR), tumour necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), superoxide dismutase 3 (SOD3), paraoxonase-1 (PON-1), stromal cell-derived factor-1α (SDF-1α) and endothelial progenitor cells (EPCs) in elderly patients with recurrent angina pectoris after coronary artery stenting.

Results: Levels of MDA, ACR, TNF-α and TLR4 were significantly increased (p<0.001), and levels of SOD3, PON-1, SDF-1α and EPCs were significantly decreased (p<0.001) in the elderly patients with recurrent angina pectoris after coronary artery stenting. MDA, ACR, TNF-α and TLR4 as markers of oxidative stress and pro-inflammatory mediators may have suppressed SOD3, PON-1, SDF-1α and EPCs as markers of anti-oxidative stress/anti-inflammatory responses. Oxidative stress and proinflammatory mediators were important factors involved in recurrent angina pectoris of elderly patients after coronary artery stenting.

Conclusion: Oxidative stress and pro-inflammatory mediators could be considered as potential noninvasive prognostic, predictive, and therapeutic biomarkers for stable recurrent angina and recurrent unstable angina in elderly patients after coronary artery stenting.

Keywords:

Pro-inflammatory mediator, oxidative stress, recurrent angina pectoris, coronary artery stenting, elderly, heart disease.

Affiliation:

Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, Department of Geriatrics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002

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