Chinwe Okeke*, Ufele Silas, Chinedu Okeke and Chiedozie Chikwendu Pages 199 - 208 ( 10 )
Advances in single-cell technology and genetic mouse models have resulted in the identification of new types of hemopoietic stem cells (HSC), resulting in baffling observations, suggesting a reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs. The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the single hierarchical differentiation route that generates functional blood types, other differentiation routes exist in-vivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has translated to it’s improved application as a therapeutic tool for various blood disorders. The reprogramming of non-hematopoietic somatic and mature blood cells to pluripotency with their subsequent differentiation into hematopoietic stem cells/progenitor cells and the introduction of new generation sequencing holds the potential for the resolution of ambiguities involved in HSC bone marrow transplantation. There is a change in the paradigm for HSC transplantation donor selection. Donor choice favors haploidentical HCT than cord blood. This review provides a general overview of the current events around hemopoietic stem cells, with emphasis on the rising trend of HSC transplantation, especially haploidentical stem cell transplantation.
Stem cells, haemopoiesis, transplantation, blood, haemopoietic, differentiation.
Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria, Nsukka, Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria, Nsukka, Haematology Department, College of Medicine,University of Abuja, Abuja, Medical Laboratory Science Department, Faculty of Health Science and Tech. University of Nigeria, Nsukka