Bingli Cheng, Yanfei Liu, Jinfan Tian, Rui Gao and Yue Liu* Pages 1 - 15 ( 15 )
Insomnia is a widespread sleep disorder in the general population, and it is a risk factor for impaired function, the development of other medical and mental disorders, and increase health care costs. In view of the health hazards of insomnia and the shortcomings of western medicine, complementary and alternative medicine (CAM) should be considered in the management of insomnia. The present overview reports the potential role of herbal medicine and non-pharmacological therapies in the treatment of insomnia and summarizes the scientific evidence reported from 2008 to 2018. PubMed and Web of Science databases were searched for studies published from 2008 to 2018. 17 randomized controlled trials and 22 non-pharmacological therapies were included in this review, and the results showed that CAM had certain advantages in the treatment of insomnia. The safety of CAM for insomnia was acceptable. Meanwhile, based on pre-clinical trial, the possible mechanism of CAM for insomnia were modulation of circadian rhythm, GABA receptor activation, antagonisms of 5-HT receptors, inhibition of glutamate-mediated pathways, and attenuation of inflammation. CAM for insomnia has made some progress, but high quality evidence-based medical evidence is still needed to provide guidance for clinical application.
Insomnia, complementary and alternative medicine, herbal medicine, clinical effects, review
Beijing Handian Pharmaceutical Co, Ltd, Beijing 100020, Graduate School of Beijing University of Chinese Medicine, Beijing 100029, Institute of Clinical Pharmacology of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, Cardiovascular diseases center, Xiyuan hospital of China academy of Chinese medical sciences, Beijing 100091