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Effects of Lipid Lowering Drugs on Arterial Stiffness. One More Way to Reduce Cardiovascular Risk?

[ Vol. 18 , Issue. 1 ]

Author(s):

Andromachi Reklou*, Niki Katsiki, Asterios Karagiannis and Vasilios Athyros   Pages 38 - 42 ( 5 )

Abstract:


Arterial stiffness (AS) is considered an independent predictor of cardiovascular disease (CVD) events.

Among lipid lowering drugs, statins have a beneficial effect on AS, independent of their hypolipidaemic effect. Based on 3 meta-analyses and other studies, this effect is compound- and dose-related. Potent statins at high doses are more effective than less powerful statins. Ezetimibe (± statin) also seems to decrease AS in patients with dyslipidaemia.

Fibrates have no effect on AS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have data that beneficially affect all AS risk factors, suggesting a beneficial effect on artery compliance. However, there is no direct measurement of their effect on AS indices.

In patients with dyslipidaemia, prescribing high dose statins (± ezetimibe) will not only decrease lowdensity lipoprotein cholesterol levels but also improve AS (in addition to other effects). This effect on AS may contribute to the observed reduction in vascular events.

Keywords:

Arterial stiffness, pulse wave velocity, augmentation index, statin, fibrate, ezetimibe, proprotein convertase subtilisin/ kexin type 9 (PCSK9), cardiovascular risk.

Affiliation:

Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Second Propedeutic Department of Internal Medicine, Hippocration Hospital, Aristotle University of Thessaloniki, Thessaloniki



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