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Should Cushing’s Syndrome be Considered as a Disease with High Cardiovascular Risk in Relevant Guidelines?

[ Vol. 18 , Issue. 1 ]

Author(s):

Goran Koracevic, Milan Stojkovic, Dragan Lovic, Milan Pavlovic, Tomislav Kostic, Marija Kutlesic, Sladjana Micic, Maja Koracevic and Milan Djordjevic*   Pages 12 - 24 ( 13 )

Abstract:


A considerable amount of data supports a 1.8-7.4-fold increased mortality associated with Cushing’s syndrome (CS). This is attributed to a high occurrence of several cardiovascular disease (CVD) risk factors in CS [e.g. adiposity, arterial hypertension (AHT), dyslipidaemia and type 2 diabetes mellitus (T2DM)]. Therefore, practically all patients with CS have the metabolic syndrome (MetS), which represents a high CVD risk. Characteristically, despite a relatively young average age, numerous patients with CS display a 'high' or 'very high' CVD risk (i.e. risk of a major CVD event >20% in the following 10 years). Although T2DM is listed as a condition with a high CVD risk, CS is not, despite the fact that a considerable proportion of the CS population will develop T2DM or impaired glucose tolerance. CS is also regarded as a risk factor for aortic dissection in current guidelines. This review considers the evidence supporting listing CS among high CVD risk conditions.

Keywords:

Cushing’s syndrome, diabetes mellitus, arterial hypertension, metabolic syndrome, cardiovascular risk factors.

Affiliation:

Department for Cardiovascular Diseases, Clinical Centre, Nis, Medical Faculty, University of Nis, Clinic for Internal Medicine Intermedica, Nis, Medical Faculty, University of Nis, Nis, Department for Cardiovascular Diseases, Clinical Centre, Nis, Center of Anaesthesiology, Clinical Centre, Nis, Medical Faculty, University of Nis, Nis, Medical Faculty, University of Nis, Nis, Health Centre Jagodina, Emergency Medical Service, Jagodina



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