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Extracellular Vesicles and Insulin Resistance: A Potential Interaction in Vascular Dysfunction

[ Vol. 17 , Issue. 5 ]

Author(s):

Tamara Sáez*, Fernando Toledo and Luis Sobrevia*   Pages 491 - 497 ( 7 )

Abstract:


Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. The extracellular vesicles include exosomes, microvesicles, and apoptotic bodies which are released to the circulation by different vascular cells. Since the cargo of extracellular vesicles seems to be altered in metabolic complications associated with insulin resistance, these vesicles may be candidates contributing to vascular insulin resistance. Despite the studies linking insulin resistance signalling pathways with the vascular effect of extracellular vesicles, the involvement of these structures in vascular insulin resistance is a phenomenon that remains unclear.

Keywords:

Insulin, insulin resistance, endothelium, vascular, extracellular vesicles, T2DM.

Affiliation:

Department of Obstetrics and Gynecology, University of Alberta, Edmonton T6G 2S2, AB, Department of Basic Sciences, Faculty of Sciences, Bío-Bío University, Chillán 3780000, Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontifical Catholic University of Chile, Santiago 8330024



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