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Galectin-3 and Arterial Stiffness in Patients with Heart Failure: A Pilot Study

[ Vol. 17 , Issue. 4 ]

Author(s):

Evangelos Oikonomou, Dimitris Karlis, Sotiris Tsalamadris, Gerasimos Siasos, Christina Chrysohoou, Georgia Vogiatzi*, Stathis Dimitropoulos, Georgios Charalambous, Evangelia Kouskouni and Dimitris Tousoulis   Pages 396 - 400 ( 5 )

Abstract:


Background: Cardiac performance depends on optimum ventriculoarterial coupling which is impaired in patients with heart failure (HF). Galectin-3 is a mediator of myocardial fibrosis and remodeling, and is associated with clinical status in patients with chronic HF. We examined the association of arterial stiffness with galectin-3 levels in patients with HF of ischemic etiology.

Methods: We consecutively enrolled 40 patients with stable ischemic HF and reduced ejection fraction. Central aortic stiffness was evaluated non-invasively by measuring carotid femoral pulse wave velocity (PWV). Among other factors, serum levels of galectin-3 and b-type natriuretic peptide (BNP) were measured.

Results: The median galectin-3 levels in our study population were 12.9 (10.8-18.7) ng/ml and the mean PWV was 9.31±2.79 m/sec. There was significant association of galectin-3 levels with age (r=0.48, p=0.003), creatinine clearance (r=-0.66, p<0.001) and BNP levels (r=0.36, p=0.05). There was a significant association of galectin-3 levels with PWV (r=0.37, p=0.03) and patients with PWV above median also had significantly increased levels of galectin-3 compared with patients with lower values of PWV [16.1(11.8-25.2) vs. 12.1(10.5-14) ng/ml, p=0.03].

Conclusion: We found an association of arterial stiffness and PWV with galectin-3 levels in patients with chronic HF of ischemic etiology. These findings suggest a pathway driving arterial stiffening and myocardial remodelling in HF. This may provide insight into the mechanism determining prognosis and clinical status of patients with HF.

Keywords:

Arterial stiffness, galectin-3, fibrosis, heart failure, pulse wave velocity, myocardial fibrosis, B-type natriuretic peptide.

Affiliation:

1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, ‘Hippokration' Hospital, National and Kapodistrian University of Athens Medical School, Athens

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