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Anti-Angiogenic Activity of Curcumin in Cancer Therapy: A Narrative Review

[ Vol. 17 , Issue. 3 ]

Author(s):

Abolfazl Shakeri, Natalie Ward, Yunes Panahi and Amirhossein Sahebkar *   Pages 262 - 269 ( 8 )

Abstract:


Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has various pharmacological activities, including, anti-inflammatory, anti-oxidant and anti-cancer properties. The anticancer effect of curcumin is attributed to activation of apoptotic pathways in cancer cells, as well as inhibition of inflammation and angiogenesis in the tumour microenvironment and suppression of tumour metastasis. Angiogenesis, which is the formation of new blood vessels from pre-existing ones, is a fundamental step in tumour growth and expansion. Several reports have demonstrated that curcumin inhibits angiogenesis in a wide variety of tumour cells through the modulation of various cell signaling pathways which involve transcription factors, protein kinases, growth factors and enzymes. This review provides an updated summary of the various pathways and molecular targets that are regulated by curcumin to elicit its anti-angiogenic activity.

Keywords:

Curcuminoids, neovascularization, cancer, vascular endothelial growth factor, angiogenesis, obesity.

Affiliation:

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, Perth, Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad

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