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Associations between Adiponectin Gene Variability, Proinflammatory and Angiogenetic Markers: Implications for Microvascular Disease Development in Type 2 Diabetes Mellitus?

[ Vol. 17 , Issue. 2 ]

Author(s):

Christina Kollia, Alexios S. Antonopoulos, Gerasimos Siasos*, Theodosia Konsola, Evangelos Oikonomou, Nikolaos Gouliopoulos, Vasiliki Tsigkou, Aggeliki Papapanagiotou, Eva Kassi, Nicholas Tentolouris, Niki Katsiki, Manolis Vavuranakis, Athanasios G. Papavassiliou and Dimitris Tousoulis   Pages 204 - 208 ( 5 )

Abstract:


Background: Adiponectin gene (ADIPOQ) variability may affect the risk for type 2 diabetes mellitus (T2DM) but it remains unclear whether it is involved in microvascular complications.

Objective: To explore the impact of ADIPOQ variability on markers of inflammation and angiogenesis in T2DM.

Methods: Overall, 220 consecutive T2DM patients from our outpatient diabetic clinic were genotyped for G276T (rs1501299) and T45G (rs2241766) single nucleotide polymorphisms of ADIPOQ gene. Serum levels of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF) were measured by enzyme-linked immunosorbent assay and high sensitivity Creactive protein (hsCRP) by immunonephelometry.

Results: Homozygosity for the G allele on rs2241766 was associated with significantly lower serum VEGF and ICAM-1 levels compared with other genotype groups, but had no effect on IL-6. Genetic variability on rs1501299 was not associated with either VEGF or ICAM-1 levels, but T homozygotes for rs1501299 had significantly lower IL-6 concentrations compared with G carriers. Furthermore, the presence of the G allele on rs2241766 was associated with significantly lower HbA1c, whereas no associations were observed for both body mass index and hsCRP with either rs2241766 or rs1501299.

Conclusion: Genetic variability on adiponectin gene was associated with serum levels of inflammatory and angiogenetic markers. Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients.

Keywords:

ADIPOQ, adiponectin, angiogenesis, diabetes mellitus, inflammation, microvascular disease.

Affiliation:

1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, First Department of Propaedeutic and Internal Medicine, Division of Diabetes, Laiko University Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Department of Biological Chemistry, National and Kapodistrian University of Athens Medical School, Athens, First Department of Propaedeutic and Internal Medicine, Division of Diabetes, Laiko University Hospital, National and Kapodistrian University of Athens Medical School, Athens, First Department of Propaedeutic and Internal Medicine, Division of Diabetes, Laiko University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Second Department of Internal Medicine, Hipokration University Hospital, Aristotle University of Thessaloniki, Thessaloniki, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Department of Biological Chemistry, National and Kapodistrian University of Athens Medical School, Athens, 1st Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens

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