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Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications

Author(s):

Muhammad A. Abdul-Ghani*, Amin Jayyousi, Ralph A. DeFronzo, Nidal Asaad and Jassim Al-Suwaidi   Pages 1 - 11 ( 11 )

Abstract:


Insulin resistance (IR) is a cardinal feature of type 2 diabetes mellitus (T2DM). It also is associated with multiple metabolic abnormalities which are known cardiovascular disease (CVD) risk factors. Thus, IR not only contributes to the development of hyperglycemia in T2DM patients, but also to the elevated CVD risk. Improving insulin sensitivity is anticipated to both lower the plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control. We review the molecular mechanisms and metabolic consequences of IR in T2DM patients and discuss the importance of addressing IR in the management of T2DM.

Keywords:

Insulin resistance, type 2 diabetes, cardiovascular disease, insulin sensitizers

Affiliation:

Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, Cardio-Metabolic Institute, 3Academic Health System, Hamad Medical Corporation, Doha, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX , Cardio-Metabolic Institute, 3Academic Health System, Hamad Medical Corporation, Doha, Cardio-Metabolic Institute, 3Academic Health System, Hamad Medical Corporation, Doha



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