Submit Manuscript  

Article Details


Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction

[ Vol. 16 , Issue. 4 ]

Author(s):

Nahuel Fernandez Machulsky, Magali Barchuk, Juan Gagliardi, Diego Gonzalez, Micaela Lombardo, Alejandro Garcia Escudero, Gerardo Gigena, Federico Blanco, Laura Schreier, Bibiana Fabre and Gabriela Berg*   Pages 355 - 360 ( 6 )

Abstract:


Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.

Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction.

Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined.

Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).

Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.

Keywords:

Vitamin D, acute myocardial infarction, matrix metalloproteinases, leptin, non HDL-cholesterol, vulnerable plaque.

Affiliation:

Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Hospital General Doctor Cosme Argerich, División de Cardiología, Unidad de Hemodinamia, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Hospital General Doctor Cosme Argerich, Division de Cardiologia, Unidad de Hemodinamia, Buenos Aires, Hospital General Doctor Cosme Argerich, Division de Cardiologia, Unidad de Hemodinamia, Buenos Aires, Hospital General Doctor Cosme Argerich, Division de Cardiologia, Unidad de Hemodinamia, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires

Graphical Abstract:



Read Full-Text article