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Vitamin D Levels in Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

[ Vol. 16 , Issue. 3 ]

Author(s):

K. Archontogeorgis, E. Nena, N. Papanas, A. Zissimopoulos, A. Voulgaris, M. Xanthoudaki, V. Manolopoulos, M. Froudarakis and P. Steiropoulos*   Pages 289 - 297 ( 9 )

Abstract:


Background: Vitamin D (Vit D) insufficiency has been implicated in the pathophysiology of numerous diseases. Obstructive sleep apnoea syndrome (OSAS), a disorder associated with increased cardiovascular and cerebrovascular morbidity, has been associated with decreased Vit D levels, but reports are inconclusive.

Aim: To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D], a marker of Vit D status, with anthropometric and sleep characteristics of OSAS patients and to compare those levels between OSAS patients and non-apnoeic controls.

Method: Consecutive subjects who had undergone polysomnography and pulmonary function testing were divided into controls (apnoea-hypopnea index, AHI <5/h) and OSAS group (AHI ≥5/h).

Results: A total of 169 subjects (135 men) were included. OSAS patients (n=139) significantly differed from non-apnoeic controls in terms of age (53.9±12.8 vs. 44.9±12.8 years, p=0.002) and body mass index (BMI) (35.9±6.9 vs. 29.9±6.8 kg/m2, p<0.001). Serum 25(OH)D levels were lower in OSAS patients (17.8±7.8 vs. 23.9±12.4 ng/ml, p=0.019). In OSAS patients, levels of serum 25(OH)D were negatively correlated with sleep stage transitions (r=-0.205, p=0.028), AHI (r=-0.187, p=0.045), oxygen desaturation index (r=-0.234, p=0.011) and percentage of time with oxyhaemoglobin saturation <90% (r=-0.172, p=0.041). In contrast, they were positively correlated with average oxyhaemoglobin saturation during sleep (r=0.179, p=0.033), forced expiratory volume in 1 sec (r=0.207, p=0.037) and oxygen partial pressure (r=0.197, p=0.029).

Conclusion: Vit D levels were lower in OSAS patients compared with non-apnoeic controls. Several indices of OSAS severity also correlated with Vit D levels.

Keywords:

Hypoxia, inflammation, obstructive sleep apnoea syndrome, sleep fragmentation, vascular complications, vitamin D.

Affiliation:

Master Programme in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Laboratory of Nuclear Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis

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