Anna Gluba-Brzozka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Gorzyn ska and Jacek Rysz Pages 123 - 134 ( 12 )
Background: Chronic kidney disease (CKD) is a worldwide public health problem and an independent risk factor for cardiovascular disease (CVD).
Objective: We assessed cardiovascular risk in end-stage renal disease (ESRD) patients and evaluated the relationship between serum uric acid (SUA) and lipoprotein subfractions.
Methods: The study group consisted of 66 patients on dialysis and a control group of 25 healthy volunteers. Concentration of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) subfractions were analysed using a Lipoprint™. Lipid profiles and SUA were measured.
Results: Statistically significant differences between control and study group both with increased and normal SUA level were observed for HDL subfractions (1-5 [p = 0.0014 – 0.0001] and 7 – 10 [p=0.016], large and small HDL subfractions [p<0.0001]), LDL-2 subfraction [p = 0.016] and IDL-B [p = 0.015]. A significant decrease by 66% in CVD prevalence was found in dialysis patients with increased level of SUA (> 428 mol/l) (p = 0.034). Association between SUA and CVD prevalence was independent of large, intermediate and small HDL subfractions as well as of very low-density lipoprotein (VLDL), intermediate- density lipoproteins-C, -B, -A (IDL-C, IDL-B and IDL-A).
Conclusion: Our study demonstrated that higher SUA level might be associated with lower prevalence of CVD among haemodialysis patients. An elevated SUA concentration in haemodialysis population may be a marker of better nutritional status and also represent the antioxidant properties SUA.
HDL, LDL subfractions, dialysis, uric acid, cardiovascular risk.
Department of Nephrology, Hypertension and Family Medicine, WAM University Hospital of Lodz, Zeromskiego 113, 90-549 Lodz