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Adiponectin: An Endothelium-Derived Vasoprotective Factor?

[ Vol. 14 , Issue. 2 ]

Author(s):

Lei Shen, Ian M. Evans, Domingos Souza, Mats Dreifaldt, Michael R. Dashwood and Mohamed-Ali Vidya   Pages 168 - 174 ( 7 )

Abstract:


Adipose tissue (AT) is now widely accepted as a key secretary organ, as well as an energy storage depot. It secretes a series of cytokines, hormones and bioactive molecules: adipokines. Adiponectin is an abundant systemic adipokine that uniquely is reduced in obesity and increases on weight loss, is anti-inflammatory, promotes insulin sensitivity and affords cardiometabolic protection. It was considered a true adipokine, in that it is exclusively generated by the adipocytes of the adipose tissue. However, recent evidence points to it being secreted by a range of other organs. This review summarizes the non-adipose sources of adiponectin especially that derived from the endothelium, its vasoprotective role and intracellular signalling pathways. Endothelium derived adiponectin may potentially be a new target for clinical intervention in cardiovascular disease.

Keywords:

Adiponectin, coronary artery bypass grafting, endothelium, perivascular adipose tissue.

Affiliation:

Life Sciences Research Division, ADLQ, P.O Box 27775, Doha, Qatar.

Graphical Abstract:



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