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Pleiotropic Effects of Statin in Therapy in Heart Failure: A Review

[ Vol. 12 , Issue. 6 ]


Michele Correale, Silvia Abruzzese, Carmen A. Greco, Morena Concilio, Matteo Di Biase and Natale D. Brunetti   Pages 873 - 884 ( 12 )


Clinical trials demonstrated that statin therapy is associated with a significant reduction in cardiovascular morbidity and mortality when used for either primary or secondary prevention of cardiovascular events. Several studies have shown that statins, having an important effect in the prevention of acute coronary syndromes, are also able to prevent heart failure (HF) in patients with coronary artery disease. This review summarizes the experimental and clinical evidence regarding the role of statins in the management of HF.


Statins, heart failure.


Department of Cardiology, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy.

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