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Therapeutic Potential and Strategies Against Leukocyte-Platelet Interaction in Atherosclerosis

[ Vol. 10 , Issue. 5 ]

Author(s):

Peter Seizer and Andreas E. May   Pages 550 - 554 ( 5 )

Abstract:


Leukocyte rolling, adhesion, transmigration and activation are features of vascular inflammation leading to atherosclerosis. In particular the interaction between platelets and leukocytes is a key process for adhesion of inflammatory cells to the vascular wall. The various mechanisms of the specific platelet-leukocyte interaction may provide a powerful target to prevent initiation and/or progression of atherosclerotic lesions.

Keywords:

Atherosclerosis, EMMPRIN, monocytes, platelets, pharmacological inhibition, inflammation, P-Selectin, clopidogrel, cytokines, chemokines

Affiliation:

Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried-Muller Str.10, 72076 Tubingen, Germany.



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